Heart attacks are the leading cause of death globally, yet some statistics from many different countries suggest these events declined in frequency since the COVID-19 pandemic. Mass General Brigham researchers evaluated whether these cardiac trends reflect a true change in event rates, or if they reflect that more people are dying at home rather than in hospitals.

Mass General Brigham researchers are shining a powerful new light into the viral darkness with the development of Luminescence CAscade-based Sensor (LUCAS), a rapid, portable, highly-sensitive diagnostic tool for processing complex biological samples. Compared to its diagnostic predecessors, LUCAS creates 500-fold stronger and 8-fold longer-lasting bioluminescence signals, overcoming longstanding challenges faced by point-of-care diagnostics. Their study published today in Nature Biomedical Engineering.

In a Perspective, Mark Hanson and Peter Gluckman explore how maternal stress, caregiving quality, and early environmental conditions can shape the development of executive functions and emotional regulation in children, and how these factors contribute to the emergence of anxiety disorders in young people. Mounting evidence reveals a significant rise in anxiety disorders among adolescents ages 12 to 19, especially in developing countries like the United States, which cannot be fully explained by contemporary stressful events like the COVID-19 pandemic. This pattern suggests that broader longer-term societal or developmental factors are driving the growing prevalence of adolescent anxiety. Here, Hanson and Gluckman highlight how environmental conditions in the earliest stages of life – beginning even before birth – can significantly shape a child’s developing brain, particularly the systems responsible for emotional regulation and executive functioning. According to the authors, these early cues may "prepare" children for adversity, but if the anticipated threats never fully materialize as they grow, such heightened emotional responses may lead to anxiety disorders, especially in adolescence. This mismatch is further compounded by the rapid and dynamic social and technological changes young people now face. “Societies face an emerging burden of mental health issues, especially in young people. Although appropriate interventions are needed to help those already affected, preventative approaches are also critical,” write Hanson and Gluckman. “Solutions will need to adopt a lifecourse perspective, involving more cohesive thinking about parental and caregiver support and the early childhood years by policymakers across health, education, and social welfare."

Many home healthcare agencies adopted telehealth services during the COVID-19 pandemic, but the absence of federal reimbursements for these services has led to an increasing number of providers discontinuing these options, a national survey conducted by the University of California, Irvine, and other institutions reveals. Results are published in Health Services Research.

Mass General Brigham researchers found that symptoms such as lingering poor appetite, trouble sleeping and coughing were more common among children with long COVID 

Prior COVID-19 vaccination did not stop the immune system from mounting a protective response to the Delta and Omicron strains, though new mutation-specific antibody production dipped slightly, according to a study led by researchers at the University of Arizona Health Sciences and published in Nature Immunology.

About The Study: This cohort study identified symptom patterns and derived research indices that were distinct between the 2 age groups (infants/toddlers [0-2 years] vs preschool-aged children [3-5 years]) and differed from those previously identified in older ages, demonstrating the need to characterize long COVID separately across age ranges. 

A new study published in JAMA Internal Medicine reveals a concerning decline in self-reported mental health among mothers in the United States between 2016 and 2023. Conducted by researchers at the Columbia University Mailman School of Public Health, the study also found modest but measurable declines in self-reported physical health during the same period.

About The Study: Between 1980 and 2023, the total number of excess U.S. deaths reached an estimated 14.7 million. Although excess deaths per year peaked in 2021, there were still more than 1.5 million during 2022 to 2023. In 2023, excess death rates remained substantially higher than pre-pandemic rates. The rising trend from 1980 to 2019 appears to have continued during and after the pandemic, likely reflecting pre-pandemic causes of death, including drug overdose, firearm injury, and cardiometabolic disease. These deaths highlight the continued consequences of U.S. health system inadequacies, economic inequality, and social and political determinants of health.

About The Study: In this cross-sectional study, 1 in 10 patients hospitalized for respiratory syncytial virus (RSV) had a concurrent acute cardiovascular event. Odds of cardiac events were significantly higher in RSV vs COVID-19 hospitalizations in both vaccine-boosted and unboosted individuals. In contemporaneous hospitalizations for RSV or influenza after the pandemic (2023-2024), odds of heart failure were significantly higher in RSV hospitalizations vs vaccine-breakthrough influenza hospitalizations. These findings suggest that patients with preexisting cardiovascular risk should consider vaccination against respiratory viral infections.