GLP-1 receptor agonists show anti-cancer benefits beyond weight loss
Peer-Reviewed Publication
Updates every hour. Last Updated: 11-May-2025 19:09 ET (11-May-2025 23:09 GMT/UTC)
*Please mention the European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14) if using this research*
New research being presented at this year’s European Congress on Obesity (ECO) in Malaga, Spain (11-14 May) and published in the journal eClinicalMedicine finds that first generation weight-loss medications like liraglutide and exenatide appear to show anti-cancer benefits beyond weight loss.
*Please mention the European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14) if using this research*
Women who experience significant weight gain after the age of 20 and either have their first child after the age of 30 or don’t have children are almost three times more likely to develop breast cancer than those who give birth earlier and whose weight remains relatively stable, new research from the UK being presented at this year’s European Congress on Obesity (ECO 2025) has found.
UH Seidman Cancer Center has been approved for funding by the Patient-Centered Outcomes Research Institute (PCORI) to implement electronic monitoring of patient’s self-reported symptoms during cancer treatment.
Led by Co-Principal Investigators Dr. Peter Pronovost, MD, PhD, UH Chief Quality and Clinical Transformation Officer, and Veale Distinguished Chair in Leadership and Clinical transformation and Melinda Hsu, MD, a medical oncologist at UH Seidman Cancer Center, this project aims to improve the quality of life and clinical outcomes for patients being treated for their cancer at UH Seidman Cancer Center by integrating electronic patient-reported outcome tools into EPIC, the electronic health record.
New research led by Irish scientists has uncovered how lipid-rich fluid in the abdomen, known as ascites, plays a central role in weakening the body’s immune response in advanced ovarian cancer. The findings offer new insights into immune suppression in ovarian cancer and open promising avenues for future immunotherapy approaches.
Over 70% of patients with ovarian cancer are diagnosed at an advanced stage, often presenting with large volumes of ascites. This ascites fluid not only supports the spread of cancer throughout the abdominal cavity but also significantly impairs the body’s immune defences. Understanding how ascites affects the immune system is important for developing better treatments that use the immune system to fight cancer.
In this recent study, researchers from Trinity College Dublin and University College Dublin explored how ascites disrupts immune cell function, with a particular focus on natural killer (NK) cells and T cells, which are key players in the body’s ability to eliminate tumours.
Chemotherapy, as one of the primary ways to treat breast cancer, can put patients at high risk of side effects that can affect their adherence to treatment and quality of life. Alternative adjuvant therapy that can alleviate this effect can be beneficial for patients. A new study published in the journal Pharmacia showed that multi-strain probiotics can have impact on chemotherapy-related side effects through improved Karnofsky performance score and Blood Urea Nitrogen in breast cancer patients with chemotherapy.